Bulut Muhammed Nurullah, Çallı Ümit, Akçay Güzide, Kıvrak Ulviye, Bulut Kezban, Özertürk Yusuf
Sağlık Bilimleri University Dr. Lütfi Kırdar Kartal Education and Research Hospital Eye Department, Istanbul, Turkey.
J Ophthalmic Vis Res. 2018 Jan-Mar;13(1):23-28. doi: 10.4103/jovr.jovr_118_16.
To investigate the effect of Ozurdex (dexamethasone intravitreal implant) on multifocal electroretinography (mfERG) findings during the treatment of macular edema secondary to the central retinal vein occlusion (CRVO).
Fifteen eyes of 15 patients who were treated with Ozurdex implant due to CRVO-related macular edema were included in this study. Best corrected visual acuity (BCVA), central macular thickness (CMT), and mfERG evaluations were performed for all patients before injection of Ozurdex. After the injection, BCVA and CMT were measured at months 3 and 6 and mfERG test was performed at month 6 for all patients.
Pre-implantation mfERG wave amplitude values of r1, r2, r3, r4 and r5 were 57.8 ± 14.8, 25.1 ± 10.6, 17.2 ± 7.3, 12.0 ± 5.0 and 7.1 ± 3.6 nV/deg, respectively. They increased to 72.9 ± 33.2, 31.2 ± 9.3, 22.6 ± 7.6, 15.6 ± 7.1 and 10.9 ± 5.7 nV/deg, respectively, at month 6. However, these increases were not statistically significant (all > 0.05). Pre-implantation mfERG r1, r2, r3, r4 and r5 wave implicit times were 40.1 ± 10.9, 39.4 ± 3, 38.4 ± 3.4, 38.2 ± 3.1 and 39.3 ± 2.2 ms, respectively and these values were measured as 38.9 ± 8.2, 38.4 ± 4.7, 37 ± 3.8, 37.5 ± 4.6 and 37.7 ± 4.7 ms at 6 months. Although there were reductions in wave implicit times in all rings, they were not statistically significant (all > 0.05).
In this prospective study, we found that the Ozurdex implant had no effect on mfERG findings 6 months after insertion for treatment of CRVO-related macular edema.
研究Ozurdex（地塞米松玻璃体内植入剂）在治疗视网膜中央静脉阻塞（CRVO）继发黄斑水肿过程中对多焦视网膜电图（mfERG）结果的影响。
本研究纳入15例因CRVO相关黄斑水肿接受Ozurdex植入治疗患者的15只眼。在注射Ozurdex前，对所有患者进行最佳矫正视力（BCVA）、中心黄斑厚度（CMT）和mfERG评估。注射后，在第3个月和第6个月测量所有患者的BCVA和CMT，并在第6个月对所有患者进行mfERG检查。
植入前mfERG的r1、r2、r3、r4和r5波振幅值分别为57.8±14.8、25.1±10.6、17.2±7.3、12.0±5.0和7.1±3.6 nV/deg。在第6个月时，它们分别增加到72.9±33.2、31.2±9.3、22.6±7.6、15.6±7.1和10.9±5.7 nV/deg。然而，这些增加无统计学意义（均P>0.05）。植入前mfERG的r1、r2、r3、r4和r5波隐时分别为40.1±10.9、39.4±3、38.4±3.4、38.2±3.1和39.3±2.2 ms，在6个月时这些值分别测量为38.9±8.2、38.4±4.7、37±3.8、37.5±4.6和37.7±4.7 ms。虽然所有环的波隐时均有缩短，但无统计学意义（均P>0.05）。
在这项前瞻性研究中，我们发现Ozurdex植入剂在植入6个月后对治疗CRVO相关黄斑水肿的mfERG结果无影响。
