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一种离子液体负载的二氧化铈纳米颗粒-碳纳米管复合材料增强的基于电化学DNA的铅检测传感器。

An ionic liquid supported CeO nanoparticles-carbon nanotubes composite-enhanced electrochemical DNA-based sensor for the detection of Pb.

作者信息

Li Yan, Liu Xiao-Rong, Ning Xiao-Hui, Huang Can-Can, Zheng Jian-Bin, Zhang Jun-Cai

机构信息

Institute of Analytical Science, Northwest University, Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Xi'an 710069, China.

Department of Chemistry, Xianyang Normal University, Xianyang, Shaanxi 712000, China.

出版信息

J Pharm Anal. 2011 Nov;1(4):258-263. doi: 10.1016/j.jpha.2011.09.001. Epub 2011 Oct 22.

DOI:10.1016/j.jpha.2011.09.001
PMID:29403707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5760794/
Abstract

An electrochemical sensor incorporating a signal enhancement for the determination of lead (II) ions (Pb) was designed on the basis of the thrombin-binding aptamer (TBA) as a molecular recognition element and ionic liquid supported cerium oxide (CeO) nanoparticles-carbon nanotubes composite modification. The composite comprises nanoparticles CeO, multi-wall carbon nanotubes (MWNTs) and hydrophobic room temperature ionic liquid (RTIL) 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF). The electrochemical sensors were fabricated by immersing the CeO-MWNTs-EMIMBF modified glassy carbon electrode (GCE) into the solution of TBA probe. In the presence of Pb, the TBA probe could form stable G-quartet structure by the specific binding interactions between Pb and TBA. The TBA-bound Pb can be electrochemically reduced, which provides a readout signal for quantitative detection of Pb. The reduction peak current is linearly related to the concentration of Pb from 1.0×10 M to 1.0×10 M with a detection limit of 5×10 M. This work demonstrates that the CeO-MWNTs-EMIMBF nanocomposite modified GCE provides a promising platform for immobilizing the TBA probe and enhancing the sensitivity of the DNA-based sensors.

摘要

基于凝血酶结合适体（TBA）作为分子识别元件以及离子液体负载的氧化铈（CeO）纳米颗粒 - 碳纳米管复合材料修饰，设计了一种用于测定铅（II）离子（Pb）并具有信号增强功能的电化学传感器。该复合材料由纳米颗粒CeO、多壁碳纳米管（MWNTs）和疏水性室温离子液体（RTIL）1 - 乙基 - 3 - 甲基咪唑四氟硼酸盐（EMIMBF）组成。通过将CeO - MWNTs - EMIMBF修饰的玻碳电极（GCE）浸入TBA探针溶液中来制备电化学传感器。在Pb存在的情况下，TBA探针可通过Pb与TBA之间的特异性结合相互作用形成稳定的G - 四联体结构。结合了Pb的TBA可以被电化学还原，这为Pb的定量检测提供了读出信号。还原峰电流与Pb浓度在1.0×10⁻⁹ M至1.0×10⁻⁷ M之间呈线性关系，检测限为5×10⁻¹⁰ M。这项工作表明，CeO - MWNTs - EMIMBF纳米复合材料修饰的GCE为固定TBA探针和提高基于DNA的传感器的灵敏度提供了一个有前景的平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/7774f2568ab1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/5b172951ef21/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/4dd9e2837ae8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/2625bdd0b56b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/735308d28ffc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/bbfc51e5fb6a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/7774f2568ab1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/5b172951ef21/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/4dd9e2837ae8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/2625bdd0b56b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/735308d28ffc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/bbfc51e5fb6a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2db/5760794/7774f2568ab1/gr6.jpg

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