Jain Rajeev, Yadav Rajeev Kumar
School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India.
J Pharm Anal. 2012 Apr;2(2):123-129. doi: 10.1016/j.jpha.2011.11.008. Epub 2011 Dec 7.
Redox behavior of midazolam was studied at a glassy carbon electrode in various buffer systems, supporting electrolytes and pH using differential pulse, square-wave and cyclic voltammetry. Based on its reduction behavior, a direct differential pulse voltammetric method has been developed and validated for the determination of midazolam in parenteral dosage. Three well-defined peaks were observed in 0.1% SLS, Britton-Robinson (BR) buffer of pH 2.5. The effect of surfactants like sodium lauryl sulfate (SLS), cetyl trimethyl ammonium bromide (CTAB) and Tween 20 was studied. Among these surfactants SLS showed significant enhancement in reduction peak. The cathodic peak currents were directly proportional to the concentration of midazolam with correlation coefficient of 0.99.
在玻碳电极上，于不同缓冲体系、支持电解质及pH条件下，运用差分脉冲伏安法、方波伏安法和循环伏安法研究了咪达唑仑的氧化还原行为。基于其还原行为，开发并验证了一种直接差分脉冲伏安法用于测定注射剂中的咪达唑仑。在pH 2.5的0.1%十二烷基硫酸钠（SLS）- Britton-Robinson（BR）缓冲液中观察到三个清晰的峰。研究了诸如十二烷基硫酸钠（SLS）、十六烷基三甲基溴化铵（CTAB）和吐温20等表面活性剂的影响。在这些表面活性剂中，SLS使还原峰显著增强。阴极峰电流与咪达唑仑浓度成正比，相关系数为0.99。
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