Department of Analytical Chemistry, Faculty of Science, Ankara University, 06100 Ankara, Turkey.
Talanta. 2001 Apr 12;54(2):351-60. doi: 10.1016/s0039-9140(00)00653-6.
A voltammetric study of the oxidation of etodolac has been carried out at the glassy carbon electrode. The electrochemical oxidation of etodolac was investigated by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy carbon electrode. Different parameters were tested to optimize the conditions for the determination of etodolac. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the buffer was investigated. For analytical purposes, a very well resolved diffusion controlled voltammetric peak was obtained in Britton-Robinson buffer at pH 2.15 for differential pulse and square wave voltammetric techniques. The linear response was obtained in the ranges of 2.10(-6)-8.10(-5) M with a detection limit of 6.8x10(-7) and 6x10(-6)-8x10(-5) M with a detection limit of 1.1x10(-6) M for differential pulse and square wave voltammetric techniques, respectively. Based on this study, simple, rapid, selective and sensitive two voltammetric methods were developed for the determination of the etodolac in tablet dosage form and human serum.
在玻碳电极上进行了依托度酸的氧化伏安研究。通过循环伏安法、线性扫描伏安法、差分脉冲伏安法和方波伏安法研究了依托度酸的电化学氧化。测试了不同参数以优化测定依托度酸的条件。研究了电流和电位强度对 pH 值、浓度、扫描速率、缓冲液性质的依赖性。对于分析目的，在 pH 2.15 的 Britton-Robinson 缓冲液中，差分脉冲和方波伏安技术可获得非常好的分辨扩散控制伏安峰。在线性范围内，可得到 2.10(-6)-8.10(-5) M 的响应，检测限分别为 6.8x10(-7)和 6x10(-6)-8x10(-5) M。基于此研究，开发了两种简单、快速、选择性和灵敏的伏安法，用于测定片剂和人血清中的依托度酸。
