Dos Santos M M Correia, Famila Vila, Gonçalves M L Simões
Centro de Química Estrutural, Instituto Superior Técnico, Av Rovisco Pais, 1049-001 Lisboa, Portugal.
Anal Bioanal Chem. 2002 Nov;374(6):1074-81. doi: 10.1007/s00216-002-1535-0. Epub 2002 Oct 3.
Direct square-wave voltammetry (SWV) and square-wave cathodic stripping voltammetry (SWCSV) at hanging mercury drop electrodes have been developed for determination of the psychoactive 1,4-benzodiazepine compounds clonazepam, bromazepam, midazolam, diazepam, medazepam, and flurazepam over a wide range of concentrations. Analysis was performed with better precision, lower detection limits, and much more rapidly than by previously reported voltammetric techniques. The applicability of both procedures is discussed. The methods were applied to the analysis of commercially available tablets with minimum sample manipulation. The accuracy of the results was accessed by comparison with those obtained by use of the methods described in official pharmacopoeias. A critical comparison with those procedures is also presented.
已开发出悬汞滴电极上的直接方波伏安法（SWV）和方波阴极溶出伏安法（SWCSV），用于在宽浓度范围内测定精神活性1,4 - 苯二氮䓬类化合物氯硝西泮、溴西泮、咪达唑仑、地西泮、美达西泮和氟西泮。与先前报道的伏安技术相比，分析具有更高的精密度、更低的检测限，且速度更快。讨论了这两种方法的适用性。这些方法应用于市售片剂的分析，样品处理最少。通过与官方药典中所述方法获得的结果进行比较来评估结果的准确性。还与那些方法进行了批判性比较。
