Wang Dong-Geng, Liu Wen-Ying, Chen Guang-Tong
Medical School, Nan Tong University, Nan Tong 226001, China.
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
J Pharm Anal. 2013 Aug;3(4):241-247. doi: 10.1016/j.jpha.2012.12.001. Epub 2012 Dec 10.
Resveratrol, a polyphenol compound with strong biological activity, has been widely used in medicine, health products and cosmetic industries. It is also the main active component of a well-known traditional Chinese medicine. We developed a simple and effective method for the preparation of resveratrol from . The whole preparative process consisted of reflux extraction, filtering, hydrolyzing, liquid-liquid extraction and eluting. Filtering is to remove non polar or less polar compounds and debris fragments from the extract. Hydrolyzing is to transform polydatin to resveratrol to improve the yield of resveratrol. Eluting is to remove impurities including strong acidic and water-soluble compounds. By acid hydrolysis of glycoside (polydatin), the yield of resveratrol increased about 4-fold. The extraction recovery in different stages was high, and the content of resveratrol in the final product was over 73.8%. Compared with other methods reported, this technology is eco-friendly, easier to perform, and also has a lower cost.
白藜芦醇是一种具有强大生物活性的多酚化合物，已广泛应用于医药、保健品和化妆品行业。它也是一种著名中药的主要活性成分。我们开发了一种从……制备白藜芦醇的简单有效方法。整个制备过程包括回流提取、过滤、水解、液液萃取和洗脱。过滤是为了从提取物中去除非极性或极性较小的化合物以及碎片。水解是为了将虎杖苷转化为白藜芦醇以提高白藜芦醇的产率。洗脱是为了去除包括强酸性和水溶性化合物在内的杂质。通过糖苷（虎杖苷）的酸水解，白藜芦醇的产率提高了约4倍。不同阶段的提取回收率较高，最终产品中白藜芦醇的含量超过73.8%。与其他报道的方法相比，该技术环保、操作更简便，成本也更低。
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