Naycı Sibel Atış, Çöplü Lütfi, Gürgün Alev, Köktürk Nurdan, Polatlı Mehmet, Şen Elif, Umut Sema, Uzaslan Esra, Yıldırım Nurhayat, Barnes Peter J
Department of Pulmonology, Mersin University Faculty of Medicine, Mersin, Turkey.
Department of Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk Thorac J. 2015 Apr;16(2):86-96. doi: 10.5152/ttd.2015.4555. Epub 2015 Apr 1.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. Research conducted over the past decade has contributed much to our current knowledge of the pathogenesis and treatment of COPD. Additionally, an evolving literature has recently accumulated information about the management of COPD and also about exacerbations. This article reviews a concise summary on the updates in COPD including 1) new pathogenic mechanisms and therapeutic targets, 2) management of patients in Group B, C and D according to GOLD 2014 report; 3) prevention and management of exacerbation; 4) monitoring of natural history; and 5) essential but usually forgotten parts of the management.
慢性阻塞性肺疾病（COPD）是全球发病和死亡的主要原因。过去十年所开展的研究极大地增进了我们目前对COPD发病机制及治疗的认识。此外，不断发展的文献最近积累了有关COPD管理以及急性加重方面的信息。本文综述了COPD的最新进展，包括：1）新的发病机制和治疗靶点；2）根据《慢性阻塞性肺疾病全球倡议（GOLD）》2014报告对B、C和D组患者的管理；3）急性加重的预防和管理；4）自然病程的监测；以及5）管理中重要但常被忽视的部分。
