Adams Paul, Howlett Christopher, Xenocostas Anargyros, Chakrabarti Subrata
University of Western Ontario London Health Sciences Center, Department of Medicine London ON Canada.
University of Western Ontario London ON Canada.
Hepatol Commun. 2017 Nov 11;2(1):13-15. doi: 10.1002/hep4.1122. eCollection 2018 Jan.
A 42-year-old man with hemochromatosis and cirrhosis developed aplastic anemia. He underwent liver transplantation from a female donor and splenectomy, and his aplastic anemia spontaneously resolved. A bone marrow examination 6 months after the liver transplant showed 17.5% female cells. He did well for 13 years without the need for any blood product support but then developed bone pain and was found to have metastatic hepatocellular carcinoma in the vertebral bodies. Molecular analysis demonstrated that the tumor cells were from his original liver. No primary liver tumor was identified in the explant. The case demonstrates the application of fluorescent hybridization with X and Y chromosome-specific probes to study chimerism and tumor origin after liver transplantation between individuals of different sex. ( 2018;2:13-15).
一名患有血色素沉着症和肝硬化的42岁男性发生了再生障碍性贫血。他接受了来自女性供体的肝移植和脾切除术，其再生障碍性贫血自发缓解。肝移植6个月后的骨髓检查显示有17.5%的女性细胞。他情况良好地度过了13年，无需任何血液制品支持，但随后出现骨痛，并且在椎体中发现有转移性肝细胞癌。分子分析表明肿瘤细胞来自他原来的肝脏。在切除的肝脏中未发现原发性肝肿瘤。该病例展示了应用X和Y染色体特异性探针进行荧光杂交来研究不同性别个体肝移植后的嵌合体现象和肿瘤起源。（2018；2：13 - 15）
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