Grierson Patrick, Crites Danielle, Ruzinova Marianna B, Yano Motoyo, Lim Kian-Huat
Division of Oncology, Department of Internal Medicine Washington University School of Medicine St. Louis MO.
Department of Pathology and Immunology Washington University School of Medicine St. Louis MO.
Hepatol Commun. 2017 Dec 19;2(2):148-151. doi: 10.1002/hep4.1132. eCollection 2018 Feb.
There are few effective therapies for unresectable or metastatic hepatocellular carcinoma. Recent data have demonstrated efficacy of immune checkpoint blockade in this difficult to treat disease; however, clinical experience is limited. We report a case of hepatocellular carcinoma displaying pseudoprogression followed by a late response with novel magnetic resonance imaging features following treatment with the anti-programmed cell death protein 1 agent pembrolizumab. ( 2018;2:148-151).
对于无法切除或转移性肝细胞癌，有效的治疗方法很少。最近的数据表明免疫检查点阻断在这种难以治疗的疾病中具有疗效；然而，临床经验有限。我们报告了一例肝细胞癌患者，在用抗程序性细胞死亡蛋白1药物帕博利珠单抗治疗后，出现了假性进展，随后出现了具有新磁共振成像特征的延迟反应。（2018年；2：148 - 151）
