Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Trends Neurosci. 2018 Feb;41(2):72-74. doi: 10.1016/j.tins.2017.11.005.
Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.
雷特综合征是一种主要影响女性的神经发育障碍,由甲基化CpG 结合蛋白 2(MECP2)基因突变引起。最初,MeCP2 被证明是基因转录的抑制剂。在他们 2008 年的论文中,Chahrour 及其同事(DOI:10.1126/science.1153252)报告称,MeCP2 也可以作为转录激活剂发挥作用。