Toxicology Research Cluster, Joan C. Edward School of Medicine, Huntington, WV, United States.
Adv Cancer Res. 2018;137:171-188. doi: 10.1016/bs.acr.2017.11.006. Epub 2017 Dec 15.
Cancer is one of the top three causes of death in the United States. The treatment regimen for controlling cancer includes a number of approaches depending on the classification of the tumor. Treatment may include radiation, surgery, and cancer chemotherapy agents as well as other interventions. Natural products have been identified for centuries to contain active pharmacologic activity and have been a starting point for numerous drugs which are currently on the market. Resveratrol (RES) is a natural product generated in plants in response to environmental stress and growing conditions. RES has been recognized since 1997 to possess anticancer activity. This review discusses the dietary sources of RES and the relative amounts present in the various food sources. A few limited clinical studies have explored RES effects in patients with prostate and colorectal cancer and have suggested some beneficial results. Future studies need to expand the sample size for clinical examination of RES in order to provide a better profile for the potential benefit of RES in cancer patients. This review also describes the potential mechanisms of RES as an antioxidant and in alteration of cell signaling. Another aspect for the role of RES in cancer may be in the interaction with cancer chemotherapy agents. Cisplatin is a cancer chemotherapy agent used for the treatment of bladder, testicular, ovarian, and many other cancers. Cisplatin usage is associated with a high risk of nephrotoxicity. Experimental studies suggest that RES may reduce cisplatin renal toxicity. The proposed mechanisms of protection are reviewed.
癌症是美国三大死亡原因之一。控制癌症的治疗方案包括许多方法，具体取决于肿瘤的分类。治疗可能包括放射治疗、手术和癌症化疗药物以及其他干预措施。几个世纪以来，人们已经发现天然产物具有有效的药理活性，并且是目前市场上许多药物的起点。白藜芦醇（RES）是植物在应对环境压力和生长条件时产生的天然产物。自 1997 年以来，人们已经认识到 RES 具有抗癌活性。本文讨论了 RES 的饮食来源以及各种食物来源中存在的相对含量。少数有限的临床研究探索了 RES 对前列腺癌和结直肠癌患者的影响，并提示了一些有益的结果。未来的研究需要扩大临床检查 RES 的样本量，以提供 RES 对癌症患者潜在益处的更好概况。本文还描述了 RES 作为抗氧化剂和改变细胞信号的潜在机制。RES 在癌症中的另一个作用可能是与癌症化疗药物相互作用。顺铂是一种用于治疗膀胱癌、睾丸癌、卵巢癌和许多其他癌症的癌症化疗药物。顺铂的使用与肾毒性的高风险相关。实验研究表明，RES 可能降低顺铂的肾毒性。本文回顾了保护的潜在机制。
