Department of Medical Oncology-Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italia.
Experimental and Clinical Pharmacology-Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italia.
Int J Mol Sci. 2020 Apr 22;21(8):2945. doi: 10.3390/ijms21082945.
Resveratrol (3,5,4'-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.
白藜芦醇（3,5,4'-三羟基二苯乙烯）是一种天然植物抗毒素，存在于坚果、葡萄、苹果、红色水果、黑橄榄、刺山柑、红米以及红酒等多种蔬菜和水果中。作为一种极其活跃的分子，并且能够与人体细胞的细胞质和核蛋白相互作用，白藜芦醇多年来一直被作为补充和替代医学（CAM）用于癌症、代谢和心血管疾病的治疗，如心肌缺血、心肌炎、心肌肥大和心力衰竭。本综述将描述白藜芦醇在临床前和临床模型中的主要生物学靶点、心血管结局、物理化学和药代动力学特性，以及其在癌症患者中的潜在应用。
