Almeida Tamires Cunha, da Silva Glenda Nicioli, de Souza Daniel Vitor, de Moraes Malinverni Andrea Cristina, Aguiar Odair, Estadella Debora, Ribeiro Daniel Araki
Laboratory of Clinical Research, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, Rua Silva Jardim, UNIFESP, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Med Oncol. 2021 Jul 17;38(8):97. doi: 10.1007/s12032-021-01548-0.
Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.
口腔癌是一种在全球范围内非常常见的肿瘤，发病率和死亡率都很高。口腔癌的治疗包括手术、放疗和化疗；然而，人们注意到其失败率高且毒性大。因此，寻找更有效治疗方法的新药备受欢迎。天然产物具有化学预防和抗癌作用。白藜芦醇是一种天然存在的抗氧化剂，具有多种健康益处，包括抗炎和抗增殖活性。这篇综述讨论了在口腔癌模型的体外和体内研究中白藜芦醇的不同作用机制。
