葡萄酒酚类化合物用于临床前抗癌治疗的机制。
The mechanisms of wine phenolic compounds for preclinical anticancer therapeutics.
作者信息
Duan Jing, Guo Hua, Fang Yulin, Zhou Guangbiao
机构信息
College of Enology, Northwest A&F University, Yangling, China.
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Food Nutr Res. 2021 Aug 23;65. doi: 10.29219/fnr.v65.6507. eCollection 2021.
BACKGROUND
Wine is one of the oldest and most popular drinks worldwide, which is rich in phenolic compounds. Epidemiological studies show that moderate consumption of wine can reduce the risk of certain diseases, and this effect is attributed to its phenolic compounds.
OBJECTIVE
The objective of this review was to elaborate the effects of wine-derived phenolic compounds for preclinical anticancer therapeutics and their major mechanisms.
METHODS
In this review, we discuss the classification and content of common phenolic compounds in wine and summarize previous studies that have evaluated the anticancer properties of wine-derived phenolic compounds and their mechanisms.
RESULTS
Wine-derived phenolic compounds have been proven to participate in several mechanisms against cancers, including deoxyribonucleic acid damage, oxidative stress, cell proliferation, cell cycle arrest, cell apoptosis, autophagy, cell invasion and metastasis, immunity and metabolism, regulation of multiple signaling molecules, and gene expression. However, the exact anticancer mechanisms of the phenolic compounds in wine need to be further investigated.
CONCLUSION
Wine-derived phenolic compounds are promising chemoprotective and chemotherapeutic agents for cancer.
背景
葡萄酒是全球最古老且最受欢迎的饮品之一，富含酚类化合物。流行病学研究表明，适度饮用葡萄酒可降低某些疾病的风险，而这种作用归因于其酚类化合物。
目的
本综述旨在阐述葡萄酒衍生酚类化合物在临床前抗癌治疗中的作用及其主要机制。
方法
在本综述中，我们讨论了葡萄酒中常见酚类化合物的分类和含量，并总结了以往评估葡萄酒衍生酚类化合物抗癌特性及其机制的研究。
结果
已证实葡萄酒衍生酚类化合物参与多种抗癌机制，包括脱氧核糖核酸损伤、氧化应激、细胞增殖、细胞周期阻滞、细胞凋亡、自噬、细胞侵袭和转移、免疫和代谢、多种信号分子的调节以及基因表达。然而，葡萄酒中酚类化合物的确切抗癌机制仍需进一步研究。
结论
葡萄酒衍生酚类化合物有望成为癌症的化学预防和化疗药物。
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