James Adele, von Oertzen Tim J, Norbury Ray, Huppertz Hans-Juergen, Brandt Karen R
Department of Psychology, Whitelands College, University of Roehampton.
Atkinson Morley Neuroscience Centre, St. George's Hospital, London, UK.
Neuroreport. 2018 Mar 21;29(5):363-367. doi: 10.1097/WNR.0000000000000974.
The present research explored the role of the medial temporal lobes in object memory in the unique patient MR, who has a selective lesion to her left lateral entorhinal cortex. Two experiments explored recognition memory for object identity and object location in MR and matched controls. The results showed that MR had intact performance in an object location task [MR=0.70, controls=0.69, t(6)=0.06, P>0.05], but was impaired in an object identity task [MR=0.62, controls=0.84, t(6)=-4.12, P<0.05]. No differences in correct recollection or familiarity emerged. These results suggest a differential role of the entorhinal cortex in object recognition memory. The current research is therefore the first patient study to show the role of the lateral entorhinal cortex in object identity recognition and suggests that current medial temporal lobe theoretical models on both object and recognition memory require a theoretical re-think to account for the contributions of the entorhinal cortex in these processes.
本研究探讨了内侧颞叶在独特患者MR的物体记忆中的作用，该患者左侧内嗅皮层存在选择性损伤。两项实验探究了MR及配对对照组对物体身份和物体位置的识别记忆。结果显示，MR在物体位置任务中表现正常[MR = 0.70，对照组 = 0.69，t(6)=0.06，P>0.05]，但在物体身份任务中受损[MR = 0.62，对照组 = 0.84，t(6)= -4.12，P<0.05]。正确回忆或熟悉度方面未出现差异。这些结果表明内嗅皮层在物体识别记忆中具有不同作用。因此，本研究是首个表明外侧内嗅皮层在物体身份识别中作用的患者研究，并表明当前关于物体和识别记忆的内侧颞叶理论模型需要进行理论反思，以解释内嗅皮层在这些过程中的作用。
