Centro de esclerosis múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
Clínica de Esclerosis Múltiple, Hospital Ramos Mejía, Buenos Aires, Argentina; Sanatorio Guemes, Buenos Aires, Argentina.
J Neurol Sci. 2018 Feb 15;385:217-224. doi: 10.1016/j.jns.2018.01.004. Epub 2018 Jan 4.
One of the biggest challenges in multiple sclerosis (MS) is the definition of treatment response/failure in order to optimize treatment decisions in affected patients. The objective of this consensus was to review how disease activity should be assessed and to propose recommendations on the identification of treatment failure in RRMS patients in Argentina.
A panel of experts in neurology from Argentina, dedicated to the diagnosis and care of MS patients, gathered both virtually and in person during 2016 and 2017 to carry out a consensus recommendation on the identification of treatment failure in RRMS patients. To achieve consensus, the methodology of "formal consensus-RAND/UCLA method" was used.
Recommendations were established based on published evidence and the expert opinion. Recommendations focused on disease management, disease activity markers and treatment failure identification were determined. Main consensus were: ≥2 relapses during the first year of treatment and/or ≥3 new or enlarged T2 or T1 GAD+ lesions and/or sustained increase of ≥2 points in EDSS or ≥100% in T25FW defines treatment failure in RRMS patients.
The recommendations of this consensus guidelines attempts to optimize the health care and management of patients with MS in Argentina.
多发性硬化症（MS）最大的挑战之一是定义治疗反应/失败，以便优化受影响患者的治疗决策。本次共识的目的是回顾如何评估疾病活动，并提出阿根廷 RRMS 患者治疗失败的识别建议。
来自阿根廷的专门从事 MS 患者诊断和护理的神经病学专家小组在 2016 年至 2017 年间通过虚拟和面对面的方式聚集在一起，就 RRMS 患者治疗失败的识别达成共识建议。为了达成共识，使用了“正式共识-RAND/UCLA 方法”的方法。
建议是基于已发表的证据和专家意见制定的。建议侧重于疾病管理、疾病活动标志物和治疗失败的识别。主要共识包括：治疗的第一年有≥2 次复发和/或≥3 个新的或扩大的 T2 或 T1 GAD+病变和/或 EDSS 持续增加≥2 分或 T25FW 增加≥100%定义为 RRMS 患者的治疗失败。
本共识指南的建议试图优化阿根廷 MS 患者的医疗保健和管理。
