Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Faculty Office Building, 49 North Dunlap Street, Room 293, Memphis, TN 38105, USA.
Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Faculty Office Building, 49 North Dunlap Street, Room 293, Memphis, TN 38105, USA.
Infect Dis Clin North Am. 2018 Mar;32(1):129-144. doi: 10.1016/j.idc.2017.11.007.
Syphilis, caused by Treponema pallidum, is transmitted both sexually and transplacentally. Untreated syphilis is a progressive disease that may result in death or disability in children and adults. Syphilis diagnosis requires 2-stage serologic testing for nontreponemal and treponemal antibodies. Congenital syphilis diagnosis requires careful review of maternal testing and treatment, comparison of maternal and neonatal nontreponemal antibody titers, and clinical evaluation of the neonate. In this review, we present the current epidemiology of syphilis, and the clinical manifestations, diagnosis, and management of syphilis as they relate to pediatric practice, specifically, congenital syphilis and acquired syphilis in adolescents and pregnant women.
梅毒是由苍白密螺旋体引起的，可通过性接触和胎盘传播。未经治疗的梅毒是一种进行性疾病，可导致儿童和成人死亡或残疾。梅毒的诊断需要进行非密螺旋体和密螺旋体抗体的 2 期血清学检测。先天性梅毒的诊断需要仔细审查母体检测和治疗情况，比较母体和新生儿的非密螺旋体抗体滴度，并对新生儿进行临床评估。在这篇综述中，我们介绍了梅毒的当前流行病学，以及梅毒与儿科实践相关的临床表现、诊断和治疗，特别是先天性梅毒和青少年及孕妇获得性梅毒。
