Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea.
Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea.
Microb Pathog. 2018 Mar;116:209-214. doi: 10.1016/j.micpath.2018.01.043. Epub 2018 Jan 31.
Multidrug-resistant (MDR) pathogens are currently causing serious problems globally in the medical setting. Improper and extensive usage of antibiotics results in a selective pressure supporting the rise of antibiotic-resistant microbes. Many key cellular bacterial components, including enzymes and small noncoding RNAs (sRNAs), and their involvement in MDR have been well studied, but exploiting such components in eradicating these pathogens requires further study. Delineation of many mechanisms that underpin the known MDR pathways necessitates urgent development of new specific strategies to control the rise of MDR pathogens. Botanical derivatives are comparatively safer than currently used antibiotics and exert multiple therapeutic benefits associated with their high efficacy. Numerous plant-derived compounds display synergistic activity with antibiotics against many MDR pathogens. Such plant derivatives include alkaloids, flavonoids, terpenoids, and tannins. A synthetic biological approach, e.g., metabolic engineering of secondary metabolites, can be utilized to exploit the natural metabolic pathways against MDR microbes. In this review, we focused on the major threats of antibiotic resistance, and the utilization of plant-derived compounds as alternative therapeutic agents to limit the rise of MDR pathogens.
多药耐药（MDR）病原体目前在全球医疗环境中造成严重问题。抗生素的不当和广泛使用导致选择性压力支持抗生素耐药微生物的兴起。许多关键的细菌细胞成分，包括酶和小非编码 RNA（sRNA），以及它们在 MDR 中的参与作用已经得到了很好的研究，但要利用这些成分来根除这些病原体，还需要进一步研究。阐明许多支持已知 MDR 途径的机制需要紧急开发新的特定策略来控制 MDR 病原体的兴起。与目前使用的抗生素相比，植物衍生化合物相对更安全，并具有多种治疗益处，与其高效性相关。许多植物衍生化合物与抗生素对多种 MDR 病原体表现出协同活性。这些植物衍生物包括生物碱、类黄酮、萜类化合物和单宁。可以利用合成生物学方法，例如次生代谢物的代谢工程，利用天然代谢途径来对抗 MDR 微生物。在这篇综述中，我们重点介绍了抗生素耐药性的主要威胁，以及利用植物衍生化合物作为替代治疗剂来限制 MDR 病原体的兴起。
