Yanishi M, Kinoshita H, Tsukaguchi H, Kimura Y, Koito Y, Jino E, Watanabe M, Sugi M, Matsuda T
Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.
Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.
Transplant Proc. 2018 Jan-Feb;50(1):150-154. doi: 10.1016/j.transproceed.2017.12.023.
Computed tomography (CT) is considered the gold standard method for the diagnosis and characterization of sarcopenia. The aim of the present study was to determine the correlation between the volume of psoas muscle measured using CT and the measurement of muscle mass with dual energy X-ray absorptiometry (DXA) and bioimpedance analysis (BIA) in kidney transplant recipients.
Fifty-eight recipients (42 males and 16 females) were enrolled. Diagnostic criteria for sarcopenia were according to those of the Asia Working Group for Sarcopenia. The volume of psoas muscle was extracted using image recognition software from three-dimensional CT images.
The volume of psoas muscle was 227.2 ± 61.3 mL in Group 1 (sarcopenia), 283.9 ± 75.3 mL in Group 2 (presarcopenia), and 363.7 ± 138.0 mL in Group 3 (without sarcopenia). Muscle mass measured using DXA was 15.80 ± 3.19 kg in Group 1, 16.36 ± 2.49 kg in Group 2, and 21.21 ± 4.14 kg in Group 3. Additionally, muscle mass assessed using BIA was 17.22 ± 4.11 kg in Group 1, 17.86 ± 3.30 kg in Group 2, and 21.48 ± 5.39 kg in Group 3. There were significant differences in the mean volume of psoas muscle between the 3 groups. There was a significant positive correlation between the volume of psoas muscle and the muscle mass assessed using DXA (r = 0.797; P < .001) and BIA (r = 0.761; P < .001). Furthermore, there was a significant positive correlation between DXA and BIA (r = 0.900; P < .001).
It was suggested that estimating muscle mass using DXA and BIA is a preferred method for diagnosis of sarcopenia in kidney transplant recipients.
计算机断层扫描（CT）被认为是诊断和鉴别肌肉减少症的金标准方法。本研究的目的是确定在肾移植受者中，使用CT测量的腰大肌体积与采用双能X线吸收法（DXA）和生物电阻抗分析（BIA）测量的肌肉质量之间的相关性。
招募了58名受者（42名男性和16名女性）。肌肉减少症的诊断标准依据亚洲肌肉减少症工作组的标准。使用图像识别软件从三维CT图像中提取腰大肌的体积。
第1组（肌肉减少症组）腰大肌体积为227.2±61.3 mL，第2组（肌肉减少症前期组）为283.9±75.3 mL，第3组（无肌肉减少症组）为363.7±138.0 mL。使用DXA测量的肌肉质量在第1组为15.80±3.19 kg，第2组为16.36±2.49 kg，第3组为21.21±4.14 kg。此外，使用BIA评估的肌肉质量在第1组为17.22±4.11 kg，第2组为17.86±3.30 kg，第3组为21.48±5.39 kg。3组之间腰大肌的平均体积存在显著差异。腰大肌体积与使用DXA评估的肌肉质量（r = 0.797；P <.001）和BIA评估的肌肉质量（r = 0.761；P <.001）之间存在显著正相关。此外，DXA和BIA之间也存在显著正相关（r = 0.900；P <.001）。
提示在肾移植受者中，使用DXA和BIA评估肌肉质量是诊断肌肉减少症的首选方法。
