Institute of Medical Microbiology, University Hospital of Münster, Domagkstraße 10, 48149 Münster, Germany.
Institute of Medical Microbiology, University Hospital of Münster, Domagkstraße 10, 48149 Münster, Germany.
Vet Microbiol. 2018 Feb;214:7-12. doi: 10.1016/j.vetmic.2017.11.032. Epub 2017 Nov 26.
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA), particularly of the clonal complex (CC) 398, emerged as zoonotic pathogens predominantly among humans with direct or indirect livestock contact, but also in healthcare settings. The factors contributing to the success of LA-MRSA are only poorly understood.
During the past years, the use of heavy metal compounds as feed-supplements was found to influence the co-selection of LA-MRSA in pig herds. This study aimed to determine the prevalence of zinc resistance among MRSA CC398 isolated from patients of a German university hospital located in a pig farming-dense area.
In comparison to concurrent healthcare-associated MRSA (HA-MRSA), LA-MRSA CC398 comprising isolates from their first appearance in 2000 to recent isolates from 2014 were included.
Among MRSA CC398, the overall resistance rate towards zinc chloride was 57% compared to only 3% among concurrently isolated HA-MRSA. Zinc resistance correlated with the presence of the czrC gene in 100% of the MRSA CC398 and in 67% of the HA-MRSA.
The zinc resistance rate in MRSA CC398 significantly increased from 2009 to 2014 with a maximum in 2014. Alarmingly, zinc resistance has become a frequent phenotype of human LA-MRSA in Germany potentially facilitating co-selection of antibiotic resistance genes.
与牲畜相关的耐甲氧西林金黄色葡萄球菌（LA-MRSA），特别是克隆复合体（CC）398，作为人畜共患病病原体，主要出现在与牲畜直接或间接接触的人群中，但也出现在医疗保健环境中。导致 LA-MRSA 成功的因素尚不完全清楚。
在过去的几年中，发现重金属化合物作为饲料添加剂的使用会影响猪群中 LA-MRSA 的共同选择。本研究旨在确定从位于养猪密集区的一家德国大学医院的患者中分离出的 MRSA CC398 对锌的耐药率。
与同期的医源性耐甲氧西林金黄色葡萄球菌（HA-MRSA）相比，包含从 2000 年首次出现到 2014 年最近分离株的 LA-MRSA CC398 被包括在内。
在 MRSA CC398 中，与同期分离的 HA-MRSA 相比，锌氯抗性的总体耐药率为 57%。锌耐药性与 czrC 基因的存在相关，在 100%的 MRSA CC398 和 67%的 HA-MRSA 中均存在该基因。
MRSA CC398 的锌耐药率从 2009 年到 2014 年显著增加，2014 年达到最高水平。令人震惊的是，锌耐药性已成为德国人类 LA-MRSA 的常见表型，可能促进了抗生素耐药基因的共同选择。
