Division Vascular Signaling and Cancer, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Medicine I, Heidelberg University Hospital, Im Neuenheimer Feld 671, 69120 Heidelberg, Germany.
National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Curr Biol. 2018 Feb 5;28(3):R119-R121. doi: 10.1016/j.cub.2017.11.065.
The vascular permeability barrier must be maintained in response to changes to vessel calibre, shear stress and blood pressure. A new study reveals a remarkable mechanism for flow-mediated regulation of permeability: Notch1 activation leads to the assembly of GTPase signalling complexes at VE-cadherin contacts and a strengthening of the endothelial barrier.
血管通透性屏障必须在血管口径、切应力和血压变化时保持稳定。一项新研究揭示了一种显著的血流介导的通透性调节机制：Notch1 激活导致 GTPase 信号复合物在 VE-钙黏蛋白连接处组装，并增强内皮屏障的稳定性。
