Department of Advanced Oral Sciences & Therapeutics, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, USA.
Nanomedicine. 2018 Apr;14(3):919-927. doi: 10.1016/j.nano.2018.01.013. Epub 2018 Feb 1.
Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and improve the penetration of dental adhesives into dentin. Such a delivery method would be less expensive, and both less painful and less traumatic than existing therapeutic options available for treatment of injured dental pulp. This technique would be simple and could be readily translated to clinical use.
维持牙髓的活力，牙髓是牙齿最内层的富含神经和血管的组织，是任何牙科手术的关键目标。在受伤后，由于牙髓被坚硬的组织包裹，因此用特定的疗法来靶向治疗牙髓具有挑战性。本项目描述了一种可以将治疗剂有效递送到牙髓的方法。该方法依赖于使用纳米颗粒，这些颗粒可以通过磁场主动引导至牙髓，通过牙本质（牙齿的中间层）中天然存在的通道进行输送。这种方法可以减轻受伤牙髓的炎症，并提高牙本质中牙科胶粘剂的渗透。与现有的治疗受伤牙髓的方法相比，这种递送方法成本更低，且痛苦和创伤更小。这种技术简单，易于转化为临床应用。
