Chacho K J, Chacho M S, Andresen P J, Scommegna A
Am J Obstet Gynecol. 1986 Jun;154(6):1290-9. doi: 10.1016/0002-9378(86)90715-5.
Peritoneal fluid from 35 women with endometriosis and from 34 control women was aspirated at laparoscopy and analyzed. No differences in prostanoid levels were found. The peritoneal fluid volume, macrophage concentration, macrophage content, and content of activated macrophages as measured by acid phosphatase staining were all significantly elevated in the endometriosis patients. The macrophages were incubated and the medium was added to the zona-free hamster egg sperm penetration assay. This medium caused a significant decrease in the percentage of ova penetrated in this assay. It is postulated that one of the mechanisms of infertility in women with endometriosis may involve the increased number of activated macrophages and their ability to interfere with sperm-egg interaction.
在腹腔镜检查时，从35名患有子宫内膜异位症的女性和34名对照女性中抽取腹腔液并进行分析。未发现前列腺素水平存在差异。子宫内膜异位症患者的腹腔液量、巨噬细胞浓度、巨噬细胞含量以及通过酸性磷酸酶染色测量的活化巨噬细胞含量均显著升高。将巨噬细胞进行培养，并将培养基添加到无透明带仓鼠卵精子穿透试验中。该培养基导致该试验中卵子被穿透的百分比显著降低。据推测，子宫内膜异位症女性不孕的机制之一可能涉及活化巨噬细胞数量的增加及其干扰精卵相互作用的能力。
