红细胞C3b受体（CR1）活性与库姆斯氏试验阳性之间的关系。
Relationships between C3b receptor (CR1) activity of erythrocytes and positive Coombs' tests.
作者信息
Inada Y, Kamiyama M, Kanemitsu T, Clark W S, Asai Y
出版信息
Ann Rheum Dis. 1986 May;45(5):367-72. doi: 10.1136/ard.45.5.367.
Although positive direct Coombs' tests occur in most patients with active systemic lupus erythematosus (SLE), haemolytic anaemic associated with antibody to erythrocytes (E) occurs in less than 10%. Our studies show an association between positive direct Coombs' tests and both the presence of circulating immune complexes and diminished activity of the C3b receptor (CR1) of E. Data presented in this report suggest that in vivo binding of immune complexes and complement by the CR1 of E results in positive direct Coombs' tests in the absence of antibody to E. These observations explain the low frequency of haemolytic anaemia compared with the high frequency of direct positive Coombs' tests in patients with SLE.
尽管大多数活动性系统性红斑狼疮（SLE）患者的直接抗人球蛋白试验呈阳性，但与抗红细胞（E）抗体相关的溶血性贫血发生率不到10%。我们的研究表明，直接抗人球蛋白试验阳性与循环免疫复合物的存在以及E的C3b受体（CR1）活性降低均有关联。本报告中的数据表明，在没有抗E抗体的情况下，E的CR1在体内与免疫复合物和补体结合会导致直接抗人球蛋白试验呈阳性。这些观察结果解释了SLE患者中溶血性贫血发生率较低而直接抗人球蛋白试验阳性率较高的现象。
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