Sugg Kristoffer B, Korn Michael A, Sarver Dylan C, Markworth James F, Mendias Christopher L
Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
FEBS Lett. 2017 Mar;591(5):801-809. doi: 10.1002/1873-3468.12571. Epub 2017 Feb 17.
The platelet-derived growth factor receptors alpha and beta (PDGFRα and PDGFRβ) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the PDGF receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited PDGFR signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
血小板衍生生长因子受体α和β（PDGFRα和PDGFRβ）分别标记骨骼肌中的纤维脂肪生成祖细胞/成纤维细胞和周细胞。虽然已经评估了这些细胞在肌肉生长和发育中所起的作用，但尚不清楚PDGF受体是否激活了在骨骼肌肥大过程中控制转录和功能变化的信号通路。为了评估这一点，我们在接受协同肌切除肌肉生长程序的小鼠中抑制PDGFR信号，并在肥大诱导后3天和10天进行分析。这项研究的结果表明，PDGF信号对于肌肉生长过程中发生的纤维肥大、细胞外基质产生和血管生成是必需的。
