Department of Cancer Biology, Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania Perelman School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 678 Haping Road, Harbin, Heilongjiang 150069, China; College of Life Science, Northeast Forestry University, 26 Hexing Road, Harbin, Heilongjiang 150040, China.
Department of Cancer Biology, Abramson Family Cancer Research Institute, Abramson Cancer Center, Institute of Diabetes, Obesity, and Metabolism (IDOM), University of Pennsylvania Perelman School of Medicine, 421 Curie Blvd., Philadelphia, PA 19104, USA.
Semin Cancer Biol. 2018 Jun;50:32-41. doi: 10.1016/j.semcancer.2018.01.018. Epub 2018 Feb 2.
FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing transcription factors (TFs). FOXOs play an important role in regulating a plethora of biological activities ranging from development, cell signaling, and tumorigenesis to cell metabolism. Here we mainly focus on reviewing the role of FOXOs in regulating tumor and metabolism. Moreover, how crosstalk among various pathways influences the function of FOXOs will be reviewed. Further, the paradoxical role for FOXOs in controlling the fate of cancer and especially resistance/sensitivity of cancer to the class of drugs that target PI3K/AKT will also be reviewed. Finally, how FOXOs regulate crosstalk between common cancer pathways and cell metabolism pathways, and how these crosstalks affect the fate of the cancer will be discussed.
FOXO 蛋白是包含 forkhead box (FOX) 的转录因子 (TF) 超家族的一个亚群。FOXOs 在调节从发育、细胞信号传导和肿瘤发生到细胞代谢等多种生物学活动中发挥着重要作用。在这里，我们主要集中讨论 FOXOs 在调节肿瘤和代谢中的作用。此外，还将回顾各种途径之间的串扰如何影响 FOXOs 的功能。进一步，还将讨论 FOXOs 在控制癌症的命运，特别是对针对 PI3K/AKT 的药物类别的癌症的耐药性/敏感性方面的矛盾作用。最后，将讨论 FOXOs 如何调节常见癌症途径和细胞代谢途径之间的串扰，以及这些串扰如何影响癌症的命运。
