Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Semin Cancer Biol. 2018 Jun;50:65-76. doi: 10.1016/j.semcancer.2018.01.004. Epub 2018 Jan 5.
FoxO transcription factors serve as the central regulator of cellular homeostasis and are tumor suppressors in human cancers. Recent studies have revealed that, besides their classic functions in promoting cell death and inducing cell cycle arrest, FoxOs also regulate cancer metabolism, an emerging hallmark of cancer. In this review, we summarize the regulatory mechanisms employed to control FoxO activities in the context of cancer biology, and discuss FoxO function in metabolism reprogramming in cancer and interaction with other key cancer metabolism pathways. A deeper understanding of FoxOs in cancer metabolism may reveal novel therapeutic opportunities in cancer treatment.
FoxO 转录因子是细胞内稳态的核心调节因子，也是人类癌症中的肿瘤抑制因子。最近的研究表明，除了在促进细胞死亡和诱导细胞周期停滞方面的经典功能外，FoxO 还调节癌症代谢，这是癌症的一个新兴标志。在这篇综述中，我们总结了控制癌症生物学中 FoxO 活性的调节机制，并讨论了 FoxO 在癌症代谢重编程中的功能以及与其他关键癌症代谢途径的相互作用。深入了解癌症代谢中的 FoxO 可能为癌症治疗提供新的治疗机会。
