在中东的一个热带和亚热带地区，疑似患有肺曲霉病的患者中，非烟曲霉属曲霉菌种占优势。
Predominance of non-fumigatus Aspergillus species among patients suspected to pulmonary aspergillosis in a tropical and subtropical region of the Middle East.
机构信息
Department of Microbiology, Islamic Azad University of Damghan, Damghan, Semnan, Iran.
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Microb Pathog. 2018 Mar;116:296-300. doi: 10.1016/j.micpath.2018.01.047. Epub 2018 Feb 1.
Non-fumigatus Aspergillus species are the leading cause of Aspergillus infections in the tropical and subtropical regions of the world. In a prospective study between 2015 and 2016, a total of 150 bronchoalveolar (BAL) specimens was collected from patients suspected to pulmonary aspergillosis (PA) underlying immunodeficiencies in Mashhad, Northeastern Iran, located in the Middle East. All Aspergillus strains were phylogenetically identified at the species level by PCR-sequencing of partial β-tubulin gene. Overall, Aspergillus species were isolated from 20 specimens originating from 10 (50%) patients with cancer, 5 (25%) patients receiving corticosteroid therapy, 3 (15%) organ transplant recipients and 2 (10%) patients admitted to intensive care unit (ICU). A. flavus complex was the predominant 15 (75%) cause of probable invasive pulmonary aspergillosis (IPA), followed by A. tubingensis 3 (15%), and 2 (10%) A. fumigates complex. In conclusion, distribution of clinical Aspergillus species in the tropical region of the Middle East shows predominance of the non-fumigatus Aspergillus spp., which warrants further attention by health care professionals.
非烟曲霉属的曲霉菌种是世界热带和亚热带地区曲霉菌感染的主要原因。在 2015 年至 2016 年期间进行的一项前瞻性研究中，从位于中东的伊朗东北部马什哈德的免疫功能低下的疑似肺部曲霉病（PA）患者中采集了总共 150 份支气管肺泡（BAL）标本。通过对部分β-微管蛋白基因的 PCR 测序，将所有曲霉菌株在种水平上进行了系统发育鉴定。总体而言，从 20 份标本中分离出了曲霉菌属，这些标本来自 10 名（50%）癌症患者、5 名（25%）接受皮质类固醇治疗的患者、3 名（15%）器官移植受者和 2 名（10%）重症监护病房（ICU）患者。黄曲霉复合体是可能的侵袭性肺曲霉病（IPA）的主要原因，有 15 例（75%），其次是构巢曲霉 3 例（15%），烟曲霉复合体 2 例（10%）。总之，中东热带地区临床曲霉菌属的分布显示出非烟曲霉属的优势，这需要医疗保健专业人员进一步关注。
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