多沙唑嗪在老年血压正常者中的药代动力学。
The pharmacokinetics of doxazosin in elderly normotensives.
作者信息
Vincent J, Meredith P A, Elliott H L, Reid J L
出版信息
Br J Clin Pharmacol. 1986 May;21(5):521-4. doi: 10.1111/j.1365-2125.1986.tb02835.x.
Abstract
The pharmacokinetics of doxazosin were studied in 12 normotensive elderly volunteers aged 62-89 years. There was marked inter-individual variability in all the parameters derived but the disposition of doxazosin was similar in both sexes. These results were compared to those of a group of young normotensive volunteers aged 23-39 years studied previously under comparable conditions. The volume of distribution increased significantly with age although the bioavailability and clearance were not significantly different in the two groups. These results suggest that age is unlikely to influence the disposition of doxazosin to a clinically significant extent.
摘要
在12名年龄在62至89岁的血压正常的老年志愿者中研究了多沙唑嗪的药代动力学。所有推导参数均存在明显的个体间差异，但多沙唑嗪在两性中的处置情况相似。将这些结果与先前在类似条件下研究的一组年龄在23至39岁的血压正常的年轻志愿者的结果进行了比较。尽管两组的生物利用度和清除率无显著差异，但分布容积随年龄显著增加。这些结果表明，年龄不太可能在临床上对多沙唑嗪的处置产生显著影响。
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