腹腔内腹水肿瘤的光动力疗法。
Photodynamic therapy of ascites tumours within the peritoneal cavity.
作者信息
Tochner Z, Mitchell J B, Smith P, Harrington F, Glatstein E, Russo D, Russo A
出版信息
Br J Cancer. 1986 Jun;53(6):733-6. doi: 10.1038/bjc.1986.126.
Abstract
A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in tumour cells than in 4 different normal tissues. A total of four HPD/laser treatments, given at 2 day intervals, resulted in 100% complete response; the cure rate was 85%. This study illustrates the effective use of intraperitoneal photodynamic therapy and opens the possibility of exploring different sensitizers, excitation wavelengths, and delivery systems in the treatment of human ascites tumours.
摘要
用腹腔内注射血卟啉衍生物（HPD）和激光（10毫瓦，514纳米，氩离子激光）治疗小鼠腹水瘤。在16分钟激光治疗前2小时腹腔内给予HPD。HPD注射后2小时的摄取研究表明，肿瘤细胞中HPD的浓度比4种不同正常组织中的浓度高5至12倍。每2天进行一次，共进行4次HPD/激光治疗，结果100%完全缓解；治愈率为85%。本研究说明了腹腔内光动力疗法的有效应用，并为探索治疗人类腹水瘤的不同敏化剂、激发波长和给药系统开辟了可能性。
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