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纤维蛋白原——急性髓系白血病（AML）中的蛋白水解作用

Fibrinogen--proteolysis in acute myelogenous leukemia (AML).

作者信息

Eckhardt T, Koch M

出版信息

Blut. 1986 Jul;53(1):39-48. doi: 10.1007/BF00320581.

DOI:10.1007/BF00320581
PMID:2941088
Abstract

Fibrinopeptides were measured as direct indices of thrombin, plasmin and elastase in plasma samples obtained from patients with AML. Peptide patterns observed were consistent with spontaneous or drug induced plasmin-specific fibrinogenolysis (AML FAB M 1/3), elastase mediated proteolysis (AML FAB M 3/4) or DIC (AML FAB 4/5). DIC was also observed in septic, agranulocytotic patients.

摘要

在从急性髓系白血病（AML）患者获取的血浆样本中，纤维蛋白肽作为凝血酶、纤溶酶和弹性蛋白酶的直接指标进行测定。观察到的肽谱与自发性或药物诱导的纤溶酶特异性纤维蛋白原溶解（AML FAB M 1/3）、弹性蛋白酶介导的蛋白水解（AML FAB M 3/4）或弥散性血管内凝血（DIC，AML FAB 4/5）一致。在脓毒症、粒细胞缺乏症患者中也观察到了DIC。

相似文献

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Fibrinogen--proteolysis in acute myelogenous leukemia (AML).纤维蛋白原——急性髓系白血病（AML）中的蛋白水解作用
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2
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Evidence of fibrinogen breakdown by leukocyte enzymes in a patient with acute promyelocytic leukemia.一名急性早幼粒细胞白血病患者中白细胞酶导致纤维蛋白原分解的证据。
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引用本文的文献

1
The importance of granulocyte elastase in haematological diagnosis.
Blut. 1988 Aug;57(2):69-75. doi: 10.1007/BF00319729.
2
Clinical significance of fibrinopeptide A in acute lymphocytic and non-lymphocytic leukaemia.纤维蛋白肽A在急性淋巴细胞白血病和非淋巴细胞白血病中的临床意义
Blut. 1989 Aug;59(2):177-83. doi: 10.1007/BF00320064.

本文引用的文献

1
Measurement of desarginine fibrinopeptide B in human blood.人体血液中去精氨酸纤维蛋白肽B的测定
J Clin Invest. 1981 Mar;67(3):809-16. doi: 10.1172/JCI110098.
2
Fibrinopeptide A in acute leukemia: relationship of activation of blood coagulation to disease activity.急性白血病中的纤维蛋白肽A：血液凝固激活与疾病活动的关系。
Blood. 1981 Mar;57(3):518-25.
3
Leukocyte elastase release during blood coagulation. A potential mechanism for activation of the alternative fibrinolytic pathway.血液凝固过程中白细胞弹性蛋白酶的释放。激活替代纤维蛋白溶解途径的一种潜在机制。
J Clin Invest. 1982 Mar;69(3):564-72. doi: 10.1172/jci110482.
4
The major fibrinolytic proteases of human leukocytes.人类白细胞的主要纤维蛋白溶解蛋白酶。
Biochim Biophys Acta. 1980 Jun 5;630(1):47-56. doi: 10.1016/0304-4165(80)90136-1.
5
Thrombin generation in acute promyelocytic leukemia.
Blood. 1984 Oct;64(4):791-6.
6
Relative proteolysis of the fibrinogen B beta chain by thrombin and plasmin as a determinant of thrombosis.凝血酶和纤溶酶对纤维蛋白原Bβ链的相对蛋白水解作用作为血栓形成的一个决定因素
Nature. 1981 May 14;291(5811):165-7. doi: 10.1038/291165a0.
7
Natural anticoagulant mechanisms.天然抗凝机制。
J Clin Invest. 1984 Jul;74(1):1-6. doi: 10.1172/JCI111389.
8
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.人髓细胞中粒细胞弹性蛋白酶和糜蛋白酶的细胞化学测定及其在获得性缺陷状态和髓系白血病诊断中的应用。
Klin Wochenschr. 1983 Jan 3;61(1):49-56. doi: 10.1007/BF01484439.
9
Anticoagulant properties of purified X-like fragments of human fibrinogen produced by degradation with leukocyte elastase.白细胞弹性蛋白酶降解产生的人纤维蛋白原纯化X样片段的抗凝特性。
Thromb Haemost. 1984 Jul 29;51(3):398-402.
10
The significance of fibrinogen derivatives in plasma in human renal failure.
Br J Haematol. 1984 Feb;56(2):251-60. doi: 10.1111/j.1365-2141.1984.tb03953.x.