Myers T J, Rickles F R, Barb C, Cronlund M
Blood. 1981 Mar;57(3):518-25.
Plasma fibrinopeptide A (FPA) levels were determined in 20 unselected adult patients with acute nonlymphocytic and lymphocytic leukemia. The mean FPA level in patients with active disease (15.0 ng/ml) was significantly higher than during clinical remission (2.4 ng/ml, p less than 0.01). Elevated FPA levels were observed in patients with all morphological forms of acute leukemia. In the group of patients in clinical remission, 20/47 FPA values remained elevated beyond the normal range, suggesting that low-grade intravascular coagulation was present even when no leukemic cells were observed. Sequential studies revealed reduction of FPA levels to the normal range in five patients who entered clinical remission after chemotherapy and rapid elevation of the levels in eight patients who entered relapse after clinical remission. FPA levels rose significantly in five patients studied during induction chemotherapy. Thus, subclinical activation of blood coagulation, as defined by elevation of plasma FPA level, may occur commonly in acute leukemia. Plasma FPA generation may relate to leukemic disease activity.
对20例未经挑选的成年急性非淋巴细胞白血病和淋巴细胞白血病患者测定了血浆纤维蛋白肽A（FPA）水平。处于疾病活动期的患者FPA平均水平（15.0 ng/ml）显著高于临床缓解期（2.4 ng/ml，p<0.01）。在所有形态学类型的急性白血病患者中均观察到FPA水平升高。在临床缓解的患者组中，47个FPA值中有20个仍高于正常范围，这表明即使未观察到白血病细胞，仍存在轻度血管内凝血。连续研究显示，5例化疗后进入临床缓解的患者FPA水平降至正常范围，8例临床缓解后进入复发期的患者FPA水平迅速升高。在诱导化疗期间研究的5例患者中，FPA水平显著升高。因此，由血浆FPA水平升高所定义的凝血亚临床激活可能在急性白血病中普遍发生。血浆FPA生成可能与白血病疾病活动有关。
