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2
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3
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利用生物材料调节趋化信号促进中枢神经系统修复。

Using biomaterials to modulate chemotactic signaling for central nervous system repair.

机构信息

School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States of America.

出版信息

Biomed Mater. 2018 Apr 27;13(4):044106. doi: 10.1088/1748-605X/aaad82.

DOI:10.1088/1748-605X/aaad82
PMID:29411713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5991092/
Abstract

Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response.

摘要

趋化作用使细胞能够在体内进行通讯和移动。本综述重点探讨了趋化作用作为一种工具，用于修复因损伤和/或退行性疾病而受损的中枢神经系统 (CNS)。趋化因子和因子本身可能会在 CNS 损伤/疾病后引发修复，但外源性给药可能会增强修复并促进再生。本综述将讨论可能促进神经再生的关键趋化性分子和因子。此外，本综述还强调了生物材料如何影响趋化因子和生长因子的呈现和传递，以改变再生反应。