Speciale A, Blandino G, Pellegrino M B, Borghi P, Caccamo F
Chemioterapia. 1986 Jun;5(3):196-9.
Ciprofloxacin's activity against 233 clinically isolated strains of both fermentative and non-fermentative bacilli was tested. In particular the authors studied the sensitivity of aminoglycoside-resistant gram-negative bacilli to ciprofloxacin. The results showed that all fermentative gram-negative bacteria were sensitive to ciprofloxacin (MICs range less than or equal to 0.02 - 1.56 mg/l). Among the non-fermentative bacilli, Pseudomonas were generally susceptible to ciprofloxacin (MIC90 less than or equal to 1.56 mg/l) except for P. cepacia and P. fluorescens (MIC90 less than or equal to 3.12 mg/l). The best antibiotic activity was shown against Moraxella, A. xylosoxidans and A. hydrophila (MICs less than or equal to 0.09 mg/l). MICs for Acinetobacter and A. faecalis were less than or equal to 1.56 mg/l while Flavobacterium were more resistant (range 1.56-3.12 mg/l). Furthermore, ciprofloxacin showed good activity against 44 aminoglycoside-resistant isolates, showing a very low (13%) incidence of resistance.
测试了环丙沙星对233株临床分离的发酵型和非发酵型杆菌的活性。特别地，作者研究了耐氨基糖苷类革兰氏阴性杆菌对环丙沙星的敏感性。结果表明，所有发酵型革兰氏阴性菌对环丙沙星敏感（MIC范围小于或等于0.02 - 1.56毫克/升）。在非发酵型杆菌中，除洋葱伯克霍尔德菌和荧光假单胞菌（MIC90小于或等于3.12毫克/升）外，铜绿假单胞菌通常对环丙沙星敏感（MIC90小于或等于1.56毫克/升）。对莫拉菌、木糖氧化无色杆菌和嗜水气单胞菌显示出最佳的抗菌活性（MIC小于或等于0.09毫克/升）。不动杆菌和粪产碱杆菌的MIC小于或等于1.56毫克/升，而黄杆菌的耐药性更强（范围为1.56 - 3.12毫克/升）。此外，环丙沙星对44株耐氨基糖苷类分离株显示出良好的活性，耐药发生率非常低（13%）。
