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一种快速制备BODIPY共轭物的合成方法及其在细胞药物摄取和分布成像中的应用。

A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution.

作者信息

Krajcovicova Sona, Stankova Jarmila, Dzubak Petr, Hajduch Marian, Soural Miroslav, Urban Milan

机构信息

Department of Organic Chemistry, Palacky University in Olomouc, Faculty of Science, 17. Listopadu 12, 77100, Olomouc, Czech Republic.

Institute of Molecular and Translational Medicine, Palacky University in Olomouc, Faculty of Medicine and Dentistry, Hnevotinska 5, 77900, Olomouc, Czech Republic.

出版信息

Chemistry. 2018 Apr 3;24(19):4957-4966. doi: 10.1002/chem.201706093. Epub 2018 Mar 12.

DOI:10.1002/chem.201706093
PMID:29411907
Abstract

A solid-phase synthetic (SPS) method was developed for the preparation of BODIPY-labeled bioactive compounds that allows for fast and simple synthesis of conjugates for use in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.

摘要

开发了一种固相合成（SPS）方法来制备硼二吡咯（BODIPY）标记的生物活性化合物，该方法能够快速简便地合成用于荧光显微镜的共轭物。该方法用于观察癌细胞中细胞毒性三萜的摄取和分布情况。

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