Synthesis of BODIPY FL-tethered ridaifen-B, RID-B-BODIPY, and its localization in cancer cells.
作者信息
Murata Takatsugu, Komukai Kyoka, Semba Yuta, Murata Eri, Sato Fumi, Takano Tomohiro, Tsuchiya Kaho, Matsuda Chihiro, Sakai Anju, Yoneoka Amane, Takahashi Shunsuke, Nagahara Yukitoshi, Shiina Isamu
机构信息
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan.
Division of Life Science and Engineering, College of Science and Engineering, Tokyo Denki University, Saitama, Japan.
出版信息
Front Chem. 2024 Aug 23;12:1451468. doi: 10.3389/fchem.2024.1451468. eCollection 2024.
We synthesized ridaifen-B boron dipyrromethene () using 2-methyl-6-nitro benzoic anhydride (MNBA)-mediated dehydration condensation reaction between amino alkyl-tethered RID and BODIPY FL. Comparative experiments between dicyclohexylcarbodiimide (DCC) and MNBA for their coupling reactions demonstrated that MNBA is an effective condensation reagent for amines and BODIPY FL. A cell staining study with showed intracellular localization of BODIPY FL fluorescence, attributed to the structure, indicating the successful development of a tool for analyzing intracellular molecular behavior efficiently.
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