• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis of BODIPY FL-tethered ridaifen-B, RID-B-BODIPY, and its localization in cancer cells.

作者信息

Murata Takatsugu, Komukai Kyoka, Semba Yuta, Murata Eri, Sato Fumi, Takano Tomohiro, Tsuchiya Kaho, Matsuda Chihiro, Sakai Anju, Yoneoka Amane, Takahashi Shunsuke, Nagahara Yukitoshi, Shiina Isamu

机构信息

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan.

Division of Life Science and Engineering, College of Science and Engineering, Tokyo Denki University, Saitama, Japan.

出版信息

Front Chem. 2024 Aug 23;12:1451468. doi: 10.3389/fchem.2024.1451468. eCollection 2024.

DOI:10.3389/fchem.2024.1451468
PMID:39246721
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377228/
Abstract

We synthesized ridaifen-B boron dipyrromethene () using 2-methyl-6-nitro benzoic anhydride (MNBA)-mediated dehydration condensation reaction between amino alkyl-tethered RID and BODIPY FL. Comparative experiments between dicyclohexylcarbodiimide (DCC) and MNBA for their coupling reactions demonstrated that MNBA is an effective condensation reagent for amines and BODIPY FL. A cell staining study with showed intracellular localization of BODIPY FL fluorescence, attributed to the structure, indicating the successful development of a tool for analyzing intracellular molecular behavior efficiently.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/2f5e3e8a2d24/fchem-12-1451468-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/3934020a645c/fchem-12-1451468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/f0b620f6c1a7/fchem-12-1451468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/d215413842d5/fchem-12-1451468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/48a6512a00fe/FCHEM_fchem-2024-1451468_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/2cf415fd4e7f/fchem-12-1451468-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/2f5e3e8a2d24/fchem-12-1451468-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/3934020a645c/fchem-12-1451468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/f0b620f6c1a7/fchem-12-1451468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/d215413842d5/fchem-12-1451468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/48a6512a00fe/FCHEM_fchem-2024-1451468_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/2cf415fd4e7f/fchem-12-1451468-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df47/11377228/2f5e3e8a2d24/fchem-12-1451468-g005.jpg

相似文献

1
Synthesis of BODIPY FL-tethered ridaifen-B, RID-B-BODIPY, and its localization in cancer cells.
Front Chem. 2024 Aug 23;12:1451468. doi: 10.3389/fchem.2024.1451468. eCollection 2024.
2
[Synthesis of BODIPY-FL-labeled phenylephrine and the determination of its biological activity].
Beijing Da Xue Xue Bao Yi Xue Ban. 2004 Dec;36(6):623-5.
3
A-D-A Type Small Molecules Based on Boron Dipyrromethene for Solution-Processed Organic Solar Cells.用于溶液处理有机太阳能电池的基于硼二吡咯亚甲基的A-D-A型小分子
Chem Asian J. 2015 Jul;10(7):1513-8. doi: 10.1002/asia.201500382. Epub 2015 Jun 5.
4
Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy.使用硼二吡咯氟-胃蛋白酶抑制剂A探测组织蛋白酶D：在荧光偏振和显微镜检查中的应用
J Biochem Biophys Methods. 2000 Mar 16;42(3):137-51. doi: 10.1016/s0165-022x(00)00048-8.
5
Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain.新型瑞代芬-B结构类似物根据吡咯烷侧链诱导细胞凋亡和自噬。
Biol Pharm Bull. 2019;42(3):401-410. doi: 10.1248/bpb.b18-00643.
6
Anti-proliferative effect of ridaifen-B on hepatoma cells.瑞代芬-B对肝癌细胞的抗增殖作用。
Biomed Rep. 2018 Aug;9(2):175-180. doi: 10.3892/br.2018.1112. Epub 2018 Jun 13.
7
Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement.新型他莫昔芬衍生物 Ridaifen-B 诱导 Bcl-2 非依赖性自噬，不涉及雌激素受体。
Biochem Biophys Res Commun. 2013 Jun 14;435(4):657-63. doi: 10.1016/j.bbrc.2013.05.040. Epub 2013 May 18.
8
Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher.基于二吡咯甲川（BODIPY）染料的 ferrocenyl 硼暗猝灭剂构建组织蛋白酶 B 响应型荧光探针和光动力试剂。
Eur J Med Chem. 2019 Oct 1;179:828-836. doi: 10.1016/j.ejmech.2019.06.082. Epub 2019 Jun 29.
9
Visual detection of transport-P in peptidergic neurones.肽能神经元中转运蛋白P的视觉检测。
Br J Pharmacol. 1997 Mar;120(5):876-82. doi: 10.1038/sj.bjp.0700970.
10
Cofacial boron dipyrromethene (Bodipy) dimers: synthesis, charge delocalization, and exciton coupling.共面硼二吡咯亚甲基（Bodipy）二聚体：合成、电荷离域和激子耦合。
J Org Chem. 2010 Mar 19;75(6):2018-27. doi: 10.1021/jo1000803.

本文引用的文献

1
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.作为有效的泛丝状病毒抑制剂的雌激素受体配体的筛选和反向工程。
J Med Chem. 2020 Oct 8;63(19):11085-11099. doi: 10.1021/acs.jmedchem.0c01001. Epub 2020 Sep 22.
2
Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids.BODIPY FL 标记三萜类化合物的设计、合成与细胞毒性。
Eur J Med Chem. 2020 Jan 1;185:111858. doi: 10.1016/j.ejmech.2019.111858. Epub 2019 Nov 6.
3
Cytostatic and Cytotoxic Natural Products against Cancer Cell Models.
针对癌细胞模型的细胞抑制剂和细胞毒素天然产物。
Molecules. 2019 May 26;24(10):2012. doi: 10.3390/molecules24102012.
4
Development of ergosterol peroxide probes for cellular localisation studies.过氧麦角甾醇探针的研制及其用于细胞定位研究。
Org Biomol Chem. 2019 May 29;17(21):5223-5229. doi: 10.1039/c9ob00145j.
5
Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain.新型瑞代芬-B结构类似物根据吡咯烷侧链诱导细胞凋亡和自噬。
Biol Pharm Bull. 2019;42(3):401-410. doi: 10.1248/bpb.b18-00643.
6
A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution.一种快速制备BODIPY共轭物的合成方法及其在细胞药物摄取和分布成像中的应用。
Chemistry. 2018 Apr 3;24(19):4957-4966. doi: 10.1002/chem.201706093. Epub 2018 Mar 12.
7
Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.瑞代芬G，他莫昔芬类似物，是一种通过与多种细胞因子组合关联起作用的强效抗癌药物。
Bioorg Med Chem. 2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5.
8
New trends in near-infrared fluorophores for bioimaging.用于生物成像的近红外荧光团的新趋势。
Anal Sci. 2014;30(3):327-49. doi: 10.2116/analsci.30.327.
9
Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement.新型他莫昔芬衍生物 Ridaifen-B 诱导 Bcl-2 非依赖性自噬，不涉及雌激素受体。
Biochem Biophys Res Commun. 2013 Jun 14;435(4):657-63. doi: 10.1016/j.bbrc.2013.05.040. Epub 2013 May 18.
10
Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.瑞达芬 B，一种他莫昔芬衍生物，直接与 Grb10 相互作用的 GYF 蛋白 2 结合。
Bioorg Med Chem. 2013 Jan 1;21(1):311-20. doi: 10.1016/j.bmc.2012.10.037. Epub 2012 Oct 29.