Department of Biological Chemistry, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
Elife. 2018 Feb 7;7:e31220. doi: 10.7554/eLife.31220.
It is well established that inducible transcription is essential for the consolidation of salient experiences into long-term memory. However, whether inducible transcription relays information about the identity and affective attributes of the experience being encoded, has not been explored. To this end, we analyzed transcription induced by a variety of rewarding and aversive experiences, across multiple brain regions. Our results describe the existence of robust transcriptional signatures uniquely representing distinct experiences, enabling near-perfect decoding of recent experiences. Furthermore, experiences with shared attributes display commonalities in their transcriptional signatures, exemplified in the representation of valence, habituation and reinforcement. This study introduces the concept of a neural transcriptional code, which represents the encoding of experiences in the mouse brain. This code is comprised of distinct transcriptional signatures that correlate to attributes of the experiences that are being committed to long-term memory.
已经证实，诱导型转录对于将显著的经验整合到长期记忆中是必不可少的。然而，诱导型转录是否传递有关正在编码的经验的身份和情感属性的信息，尚未得到探索。为此，我们分析了多种奖赏和厌恶体验在多个大脑区域诱导的转录。我们的结果描述了存在强大的转录特征，这些特征独特地代表不同的经验，能够近乎完美地解码最近的经验。此外，具有共同属性的经验在其转录特征中表现出共同之处，例如在效价、习惯化和强化方面的表现。这项研究引入了神经转录密码的概念，它代表了在老鼠大脑中经验的编码。这个代码由与正在被长期记忆所记录的经验的属性相关的独特转录特征组成。
