Shymansky Tamila, Hughes Emily, Rothwell Cailin M, Lukowiak Ken
Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Neurobiol Learn Mem. 2018 Mar;149:1-9. doi: 10.1016/j.nlm.2018.01.010. Epub 2018 Feb 3.
The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the invertebrate model Lymnaea to study propranolol's ability to disrupt consolidation of memories formed under varying various types of stress which cause differing degrees of emotional memory. We show that when propranolol is administered immediately following operant conditioning, only the consolidation process of memories enhanced by individual stressors (i.e. a non-emotional memory) is susceptible to disruption. However, when propranolol is administered prior to training, only memories enhanced by a combination of stressors leading to an emotional memory are susceptible to disruption. These data suggest that the time of propranolol administration, as well as the type of memory formed play a key role in propranolol's ability to obstruct memory consolidation.
合成β-肾上腺素能受体阻滞剂普萘洛尔治疗创伤后应激障碍（PTSD）的疗效目前存在争议。关于普萘洛尔破坏记忆巩固和再巩固能力的研究结果不一。在此，我们使用无脊椎动物模型椎实螺来研究普萘洛尔破坏在不同类型应激下形成的记忆巩固的能力，这些应激会导致不同程度的情绪记忆。我们发现，在操作性条件反射后立即给予普萘洛尔时，只有由个体应激源增强的记忆（即非情绪记忆）的巩固过程容易受到破坏。然而，当在训练前给予普萘洛尔时，只有由导致情绪记忆的应激源组合增强的记忆容易受到破坏。这些数据表明，普萘洛尔给药的时间以及形成的记忆类型在其阻碍记忆巩固的能力中起着关键作用。
