Hauschild Daniela Barbieri, Rosa Anauã Franco, Ventura Julia Carvalho, Barbosa Eliana, Moreira Emília Addison Machado, Ludwig Neto Norberto, Moreno Yara Maria Franco
Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brasil.
Rev Paul Pediatr. 2018 Jan 15;36(1):8. doi: 10.1590/1984-0462/;2018;36;1;00006. Print 2018 Jan-Mar.
To evaluate the association between nutritional status, lung function and morbidity in a 36-month cohort in children and adolescents with cystic fibrosis.
Prospective cohort of children and adolescents with cystic fibrosis aged 1-15 years. At the baseline, the nutritional status was determined by weight-for-height and body mass index-for-age for children <2 years and ≥2 years, respectively, and classified as: nutritional failure, nutritional risk and acceptable; and by the 50th percentile, according to the World Health Organization (WHO) growth charts. Lung function was assessed by forced expiratory volume in one second (FEV1). Morbidity was determined by the presence of infection and hospitalization by pulmonary exacerbation. Risk ratio and 95% confidence interval (95%CI) were calculated, being significant when p<0.05.
We evaluated 38 children and adolescents (median age 3.8 years). Patients that were classified as having nutritional failure at baseline had a RR of 5.00 (95%CI 1.49; 16.76) to present impaired lung function after 36 months. Those classified bellow the 50th percentile had a RR of 4.61 (95%CI 0.89; 23.81) to present the same outcome. Nutritional status was not a risk factor for morbidity in this cohort.
Nutritional deficit was associated with impaired lung function, but not with morbidity in children and adolescents with cystic fibrosis.
评估囊性纤维化儿童和青少年36个月队列研究中营养状况、肺功能与发病率之间的关联。
对1至15岁的囊性纤维化儿童和青少年进行前瞻性队列研究。基线时，分别根据身高别体重和年龄别体重指数来确定2岁及以下和2岁以上儿童的营养状况，并分类为：营养衰竭、营养风险和可接受；并根据世界卫生组织（WHO）生长图表的第50百分位数进行分类。通过一秒用力呼气量（FEV1）评估肺功能。通过感染的存在和肺部加重导致的住院情况来确定发病率。计算风险比和95%置信区间（95%CI），当p<0.05时具有统计学意义。
我们评估了38名儿童和青少年（中位年龄3.8岁）。基线时被分类为营养衰竭的患者在36个月后出现肺功能受损的风险比为5.00（95%CI 1.49；16.76）。那些低于第50百分位数的患者出现相同结果的风险比为4.6（95%CI 0.89；23.81）。在这个队列中，营养状况不是发病的危险因素。
营养缺乏与囊性纤维化儿童和青少年的肺功能受损有关，但与发病率无关。
