Division of Gastroenterology, Hepatology and Nutrition, School of Health and Rehabilitation Sciences, The Ohio State University, 453 West 10th Avenue, Columbus, OH 43210, USA.
School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, 453 West 10th Avenue, Columbus, OH 43210, USA.
Gastroenterol Clin North Am. 2018 Mar;47(1):77-94. doi: 10.1016/j.gtc.2017.10.002. Epub 2017 Dec 6.
The goal of nutritional support in acute pancreatitis is to reduce inflammation, prevent nutritional depletion, correct a negative nitrogen balance, and improve outcomes. Enteral nutrition (EN) in severe acute pancreatitis (SAP) should be preferred to parenteral nutrition. It maintains the integrity of the gut barrier, decreases intestinal permeability, downregulates the systemic inflammatory response, maintains intestinal microbiota equilibrium, and reduces the complications of the early phase of SAP, improving morbidity and possibly improving mortality, and it is less expensive. Further studies to understand optimal timing of nutrition, route of delivery of EN, and the type of nutrition and nutrients are necessary.
急性胰腺炎的营养支持目标是减轻炎症、防止营养耗竭、纠正负氮平衡和改善预后。在重症急性胰腺炎（SAP）中，应优先选择肠内营养（EN）而非肠外营养。EN 可维持肠道屏障的完整性，降低肠道通透性，下调全身炎症反应，维持肠道微生物群平衡，减少 SAP 早期阶段的并发症，降低发病率，可能改善死亡率，而且费用更低。需要进一步研究以了解营养的最佳时机、EN 的输送途径以及营养和营养素的类型。
