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移植性白血病小鼠血清和肝脏中的非磷酸化转葡萄糖基作用

Non-phosphorylative transglucosylation in the serum and liver of mice with transplantable leukaemias.

作者信息

Kotoński B, Madej J A, Sobiech K A, Kaszubkiewicz C

出版信息

Folia Histochem Cytobiol. 1986;24(1):15-20.

PMID:2941319
Abstract

Transglucosylative activity was examined in the serum and liver of mice with transplantable leukaemias, using following synthetic substrates: p-nitrophenyl-N-maltoside, as well as p-nitrophenyl-N-glucoside and maltose. In the serum of mice with leukaemias L 1210/ara-C and L 1210/CH3G as well as lymphoma AKSL-4 and plasmocytoma ADJ PC-5 there was observed a statistically significant decrease in the transglucosylative activity compared with the control group. Examination of extracts from the liver of mice proved increased transglucosylative activity at leukaemias L 1210/ara-C and AKSL-4. No significant changes in the transglucosylative activity were found at leukaemias L 1210/CH3G and ADJ PC-5.

摘要

使用以下合成底物,对患有可移植性白血病的小鼠血清和肝脏中的转葡糖基活性进行了检测:对硝基苯基 - N - 麦芽糖苷,以及对硝基苯基 - N - 葡萄糖苷和麦芽糖。与对照组相比,在患有白血病L 1210/ara - C和L 1210/CH3G以及淋巴瘤AKSL - 4和浆细胞瘤ADJ PC - 5的小鼠血清中,观察到转葡糖基活性有统计学意义的下降。对小鼠肝脏提取物的检测证明,在白血病L 1210/ara - C和AKSL - 4中,转葡糖基活性增加。在白血病L 1210/CH3G和ADJ PC - 5中,未发现转葡糖基活性有显著变化。

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