通过 NMR 方法检测和定量运动膳食补充剂中的苯乙胺类物质。
Detection and quantification of phenethylamines in sports dietary supplements by NMR approach.
机构信息
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
出版信息
J Pharm Biomed Anal. 2018 Mar 20;151:347-355. doi: 10.1016/j.jpba.2018.01.025. Epub 2018 Jan 31.
Phenethylamines (PEAs) are popular substances found in weight-loss and sports nutrition supplements. They are generally pharmacologically active and primarily affect the sympathetic nervous system. Many PEAs are synthetic chemicals and are on the prohibited list of the World Anti-Doping Agency. In this study, nuclear magnetic resonance (NMR) spectroscopy was applied to detect and identify the presence of PEAs in sports dietary supplements without the need for chromatographic separation or pre-knowledge on formulation. Eight PEAs, viz. phenethylamine, synephrine, oxilofrine, hordenine, β-methylphenethylamine, N-methyltyramine, octopamine and deterenol, were identified from 32 dietary supplements sold in the US market. Furthermore, a quantitative NMR method was developed and validated for simultaneous determination of the concentrations of the PEAs. The study demonstrated that NMR could be a potential tool to monitor and detect PEAs or other ingredients in dietary supplements.
苯乙胺（PEAs）是在减肥和运动营养补充剂中发现的流行物质。它们通常具有药理学活性，主要影响交感神经系统。许多苯乙胺是合成化学品，并且在世界反兴奋剂机构的禁用清单上。在这项研究中，核磁共振（NMR）光谱用于检测和识别运动营养补充剂中 PEAs 的存在，而无需进行色谱分离或预先了解配方。从美国市场上销售的 32 种膳食补充剂中鉴定出 8 种苯乙胺，即苯乙胺、辛弗林、奥洛福林、麦角乙二胺、β-甲基苯乙胺、N-甲基酪胺、章鱼胺和去甲肾上腺素。此外，还开发和验证了一种定量 NMR 方法，用于同时测定 PEAs 的浓度。该研究表明，NMR 可能是监测和检测膳食补充剂中 PEAs 或其他成分的潜在工具。
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