Stewart F, Bohlken S, Begg A, Bartelink H
Int J Radiat Oncol Biol Phys. 1986 Jun;12(6):927-33. doi: 10.1016/0360-3016(86)90387-1.
Functional kidney damage in mice was measured (using clearance of 51Cr-EDTA) from 1 to 39 weeks after treatment with single doses of cisplatinum (c-DDP), X rays, or their combination. After c-DDP alone renal damage was observed within 1 week. From 1 to 7 weeks there was recovery of function after low drug doses but after doses in excess of 6 mg/kg some damage persisted. After irradiation alone there was no measurable change in function for 20 weeks. Beyond this time there was a dose dependent and progressive deterioration of function. c-DDP given before or after irradiation caused more damage than either agent alone. During the first 20 weeks independent toxicities accounted for most of this effect but at later times modification of radiation damage possibly contributed. The greatest enhancements were observed when c-DDP was given 1/2 hour before to 1 day after irradiation (Dose Modifying Factor, DMF, 1.3). c-DDP given 3 to 4 weeks before X rays caused only a slight enhancement of damage (DMF 1.1).
在用单剂量顺铂（c-DDP）、X射线或其联合治疗后的1至39周内，（通过51Cr-EDTA清除率）测定了小鼠的功能性肾损伤。单独使用c-DDP后，1周内观察到肾损伤。低剂量药物治疗后，1至7周功能有所恢复，但剂量超过6mg/kg后，一些损伤持续存在。单独照射后，20周内功能无明显变化。在此之后，功能出现剂量依赖性和进行性恶化。照射前或照射后给予c-DDP比单独使用任何一种药物造成的损伤都更大。在最初的20周内，这种效应主要由独立毒性引起，但在后期，辐射损伤的改变可能也有作用。当在照射前半小时至照射后1天给予c-DDP时，观察到最大程度的增强（剂量修正因子，DMF，1.3）。在X射线照射前3至4周给予c-DDP仅导致损伤略有增强（DMF 1.1）。
