Stewart F A, Bartelink H, van der Voet G B, de Wolff F A
Division of Experimental Therapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.
Radiother Oncol. 1991 Aug;21(4):277-81. doi: 10.1016/0167-8140(91)90054-k.
Doses of 4-6 mg kg-1 c-DDP given 6 months before renal irradiation caused only a modest increase in functional radiation damage (DEF 1.1). These effects could be explained by additive toxicities and the damage was much less than when c-DDP was given 3-6 months after irradiation. Pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.
在肾脏照射前6个月给予4 - 6毫克/千克的顺铂剂量，仅导致功能性辐射损伤适度增加（剂量效应因子为1.1）。这些效应可以用相加毒性来解释，且损伤远小于在照射后3 - 6个月给予顺铂时的情况。药代动力学研究未显示先前低剂量肾脏照射后铂清除率有任何降低。
