Professorial Medical Unit, Colombo South Teaching Hospital, Colombo, Sri Lanka.
Professorial Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
J Clin Virol. 2018 Apr;101:1-6. doi: 10.1016/j.jcv.2018.01.001. Epub 2018 Jan 6.
Dengue is a significant health problem in many countries. In recent years, complications involving specific organ systems have been increasingly observed and appear to have important effects on overall dengue related morbidity and mortality. Renal involvement in dengue could potentially cause increased mortality and long term effects. We review the different renal manifestations associated with dengue virus infections and explore their potential underlying pathophysiological mechanisms. The serum electrolyte and urinary abnormalities seen in dengue are discussed and Acute Kidney Injury (AKI) due to acute glomerulonephritis, rhabdomyolysis and haemolytic uraemic syndrome following dengue are explored. Renal manifestations of dengue in patients with chronic kidney disease or a transplanted kidney provides new insights into the pathophysiology of the disease.
登革热是许多国家的一个重大卫生问题。近年来，涉及特定器官系统的并发症越来越多地被观察到，并且似乎对整体登革热相关发病率和死亡率有重要影响。肾脏受累可能会导致登革热患者死亡率增加和长期影响。我们回顾了与登革热病毒感染相关的不同肾脏表现，并探讨了它们潜在的病理生理机制。本文讨论了登革热患者血清电解质和尿液异常，并探讨了急性肾小球肾炎、横纹肌溶解和溶血尿毒综合征导致的急性肾损伤。慢性肾脏病或移植肾患者登革热的肾脏表现为该疾病的病理生理学提供了新的见解。
