F-氟米索硝唑动态PET的房室动力学分析中操作者间的变异性。

Inter-operator variability in compartmental kinetic analysis of F-fluoromisonidazole dynamic PET.

作者信息

Nehmeh Sadek A, Schwartz Jazmin, Grkovski Milan, Yeung Ivan, Laymon Charles M, Muzi Mark, Humm John L

机构信息

Weill Cornell Medical College, New York, NY, United States.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

出版信息

Clin Imaging. 2018 May-Jun;49:121-127. doi: 10.1016/j.clinimag.2017.12.015. Epub 2018 Jan 12.

PURPOSE

To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET.

METHODS

Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed.

RESULTS

Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs. Study-II: Up to 103% variability in tumor segmentation, and weaker ICC in KRCs (ICC-V = 0.53; ICC-K = 0.91; ICC-K/k = 0.25; ICC-k3 = 0.32; ICC-K = 0.54) existed. All KRCs were repeatable among the different operators.

CONCLUSIONS

Inter-operator variability in CA of dyn-FMISO was shown to be within statistical errors.

目的

评估动态氟代脱氧胸苷（dyn-FMISO）PET的房室分析（CA）中操作者间的变异性。

方法

研究I：五名研究者对23例非小细胞肺癌（NSCLC）dyn-FMISO肿瘤时间-活性曲线进行了CA分析。研究II：四名操作者对四个NSCLC dyn-FMISO数据集进行了CA分析。评估了动力学速率常数（KRCs）的重复性。

结果

研究I：所有KRCs在操作者之间存在强相关性（组内相关系数[ICC]＞0.9）且结果可互换。研究II：肿瘤分割存在高达103%的变异性，KRCs中的ICC较弱（ICC-V = 0.53；ICC-K = 0.91；ICC-K/k = 0.25；ICC-k3 = 0.32；ICC-K = 0.54）。所有KRCs在不同操作者之间是可重复的。