Advanced Manufacturing Technologies, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, United States.
Advanced Manufacturing Technologies, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, United States.
Curr Opin Chem Biol. 2018 Apr;43:127-133. doi: 10.1016/j.cbpa.2018.01.008. Epub 2018 Feb 3.
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.
自然界已经开发出了一套强大的酰胺键形成工具包，可用于各种适用于小分子合成的断开反应。尽管如此，生物催化技术在工业合成中的应用仍然仅限于少数几个非常重要的情况。本文讨论了先前报道的生物催化合成酰胺键的技术，综述了这些技术在工业规模放大方面的实例，并确定了在当前技术水平下，这些技术在可扩展性方面存在的一些局限性。
