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现代癫痫手术治疗算法:整合传统与新兴技术。

A modern epilepsy surgery treatment algorithm: Incorporating traditional and emerging technologies.

机构信息

Department of Neurological Surgery, Vanderbilt University Medical Center, 1500 21st Avenue South, 4340 Village at Vanderbilt, Nashville, TN 37212, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1500 21st Avenue South, 4340 Village at Vanderbilt, Nashville, TN 37212, USA; Department of Biomedical Engineering, Vanderbilt University Medical Center, 1500 21st Avenue South, 4340 Village at Vanderbilt, Nashville, TN 37212, USA; The Vanderbilt Epilepsy Center, Vanderbilt University Medical Center, 1500 21st Avenue South, 4340 Village at Vanderbilt, Nashville, TN 37212, USA.

出版信息

Epilepsy Behav. 2018 Mar;80:68-74. doi: 10.1016/j.yebeh.2017.12.041. Epub 2018 Feb 2.

Abstract

Epilepsy surgery has seen numerous technological advances in both diagnostic and therapeutic procedures in recent years. This has increased the number of patients who may be candidates for intervention and potential improvement in quality of life. However, the expansion of the field also necessitates a broader understanding of how to incorporate both traditional and emerging technologies into the care provided at comprehensive epilepsy centers. This review summarizes both old and new surgical procedures in epilepsy using an example algorithm. While treatment algorithms are inherently oversimplified, incomplete, and reflect personal bias, they provide a general framework that can be customized to each center and each patient, incorporating differences in provider opinion, patient preference, and the institutional availability of technologies. For instance, the use of minimally invasive stereotactic electroencephalography (SEEG) has increased dramatically over the past decade, but many cases still benefit from invasive recordings using subdural grids. Furthermore, although surgical resection remains the gold-standard treatment for focal mesial temporal or neocortical epilepsy, ablative procedures such as laser interstitial thermal therapy (LITT) or stereotactic radiosurgery (SRS) may be appropriate and avoid craniotomy in many cases. Furthermore, while palliative surgical procedures were once limited to disconnection surgeries, several neurostimulation treatments are now available to treat eloquent cortical, bitemporal, and even multifocal or generalized epilepsy syndromes. An updated perspective in epilepsy surgery will help guide surgical decision making and lay the groundwork for data collection needed in future studies and trials.

摘要

近年来,癫痫手术在诊断和治疗程序方面取得了许多技术进步。这增加了可能适合干预和提高生活质量的患者数量。然而,该领域的扩展还需要更广泛地了解如何将传统和新兴技术纳入综合癫痫中心提供的护理中。本综述使用示例算法总结了癫痫的新旧手术程序。虽然治疗算法本质上过于简化、不完整且反映了个人偏见,但它们提供了一个通用框架,可以根据每个中心和每个患者的情况进行定制,包括提供者意见、患者偏好和机构技术可用性的差异。例如,微创立体定向脑电图 (SEEG) 的使用在过去十年中急剧增加,但许多情况下仍受益于使用硬膜下网格进行有创记录。此外,尽管手术切除仍然是局灶性内侧颞叶或新皮质性癫痫的金标准治疗方法,但在许多情况下,消融性手术如激光间质热疗 (LITT) 或立体定向放射手术 (SRS) 可能是合适的,并可避免开颅手术。此外,虽然姑息性手术曾经仅限于切断手术,但现在有几种神经刺激治疗方法可用于治疗运动皮质、双颞叶,甚至多灶性或全身性癫痫综合征。癫痫手术的最新观点将有助于指导手术决策,并为未来的研究和试验奠定数据收集的基础。

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