Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
J Intern Med. 2018 May;283(5):489-499. doi: 10.1111/joim.12739. Epub 2018 Mar 12.
Multimorbidity is among the most disabling geriatric conditions. In this study, we explored whether a rapid development of multimorbidity potentiates its impact on the functional independence of older adults, and whether different sociodemographic factors play a role beyond the rate of chronic disease accumulation.
A random sample of persons aged ≥60 years (n = 2387) from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) was followed over 6 years. The speed of multimorbidity development was estimated as the rate of chronic disease accumulation (linear mixed models) and further dichotomized into the upper versus the three lower rate quartiles. Binomial negative mixed models were used to analyse the association between speed of multimorbidity development and disability (impaired basic and instrumental activities of daily living), expressed as the incidence rate ratio (IRR). The effect of sociodemographic factors, including sex, education, occupation and social network, was investigated.
The risk of new activity impairment was higher among participants who developed multimorbidity faster (IRR 2.4, 95% CI 1.9-3.1) compared with those who accumulated diseases more slowly overtime, even after considering the baseline number of chronic conditions. Only female sex (IRR for women vs. men 1.6, 95% CI 1.2-2.0) and social network (IRR for poor vs. rich social network 1.7, 95% CI 1.3-2.2) showed an effect on disability beyond the rate of chronic disease accumulation.
Rapidly developing multimorbidity is a negative prognostic factor for disability. However, sociodemographic factors such as sex and social network may determine older adults' reserves of functional ability, helping them to live independently despite the rapid accumulation of chronic conditions.
多种疾病是最具致残性的老年疾病之一。在这项研究中,我们探讨了多种疾病快速发展是否会增强其对老年人功能独立性的影响,以及不同的社会人口因素是否在慢性病积累率之外发挥作用。
从瑞典 Kungsholmen 老龄化和护理全国研究(SNAC-K)中随机抽取年龄≥60 岁的人员(n=2387)进行了 6 年的随访。通过线性混合模型来估计多种疾病发展的速度,即慢性病积累的速度,并进一步将其分为上四分位数与三个下四分位数。使用二项负混合模型来分析多种疾病发展速度与残疾(基本和工具性日常生活活动受损)之间的关系,用发病率比(IRR)表示。还调查了社会人口因素(包括性别、教育、职业和社交网络)的影响。
与慢性病积累速度较慢的参与者相比,多种疾病快速发展的参与者发生新的活动障碍的风险更高(IRR 2.4,95%CI 1.9-3.1),即使考虑了基线慢性病的数量也是如此。只有性别(女性 vs. 男性的 IRR 为 1.6,95%CI 1.2-2.0)和社交网络(社交网络较差 vs. 较好的 IRR 为 1.7,95%CI 1.3-2.2)对残疾的影响超出了慢性病积累率。
快速发展的多种疾病是残疾的一个负面预后因素。然而,社会人口因素,如性别和社交网络,可能决定了老年人的功能能力储备,使他们即使在慢性病迅速积累的情况下也能独立生活。