Dietz R, Lang R E, Purgaj J, Merkel A, Schömig A, Kübler W
J Hypertens Suppl. 1986 Dec;4(6):S512-5.
Plasma concentrations of the atrial natriuretic peptide (ANP) were measured during cardiac catheterization in 289 patients with heart disease. It was elevated in all types of cardiac disease investigated, irrespective of the nature and duration of the disease. Close relationships were observed between the elevated ANP concentrations and the increased right and/or left atrial pressure. Further increments in ANP concentration were measured during exercise in direct response to the rise in mean pulmonary artery pressure. Thus, ANP concentrations may be regarded as a non-invasive marker of the haemodynamic burden in cardiac disease.
在对289例心脏病患者进行心导管检查期间，测量了血浆心钠素（ANP）浓度。在所研究的所有类型心脏病中，其浓度均升高，与疾病的性质和病程无关。观察到升高的ANP浓度与右心房和/或左心房压力升高之间存在密切关系。在运动期间，随着平均肺动脉压升高，ANP浓度进一步升高。因此，ANP浓度可被视为心脏病血流动力学负担的无创标志物。
